Table 5.
Robustness analysis of miRNA within each species
| Species | Ns | Length | %GC | No. of genetically robust miRNAs (%) | No. of environmentally robust miRNAs (%) |
| H. sapiens | 242 | 85.48 ± 14.49 | 47.67 ± 7.88 | 177(73.1) | 233(96.3) |
| C. elegans | 112 | 98.29 ± 6.42 | 44.61 ± 6. 89 | 93(83.0) | 74(66.1) |
| D. melanogaster | 75 | 87.67 ± 12.74 | 41.60 ± 5.39 | 54(72.0) | 48(64.0) |
| D. rerio | 350 | 94.36 ± 18.49 | 45.11 ± 6.51 | 254(72.6) | 254(72.6) |
| M. musculus | 191 | 80.26 ± 12.48 | 48.19 ± 8.26 | 130(68.1) | 177(92.7) |
| R. norvegicus | 112 | 90.96 ± 9.14 | 50.34 ± 7.96 | 77(68.8) | 105(93.8) |
Ns, total number of experimentally verified miRNA sequences; Length, distribution of miRNA sequence length; %GC, distribution of GC content of miRNA sequences; No. of genetically (environmentally) robust miRNAs (%), the number of significantly genetically (environmentally) robust miRNAs (%) at FDR-controlled P-value of < 0.05, comparing with random pseudo pre-miRNAs.