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. 1999 Jul 6;96(14):8283–8288. doi: 10.1073/pnas.96.14.8283

Figure 2.

Figure 2

CRH KO mice have normal behavioral responses to stress and to i.c.v. CRH. (A and B) MCC. Basal activity (time per contact) of CRH KO and WT mice is equivalent (A, Basal) and decreases to a similar extent in both genotypes after a 30-min restraint (A, Restraint). Activity after i.c.v. injection of vehicle is similar in WT and CRH KO mice (B, Vehicle) and decreases significantly to the same extent in both genotypes after i.c.v. injection of CRH (B, CRH). (C) EPM. Basally, the time spent in the open arms was equivalent in WT and CRH KO (C, Basal), and it significantly decreases in both genotypes to the same degree after a 30-min restraint (C, Restraint). In A–C, WT, closed bars; CRH KO, open bars.