CRH KO mice exhibit normal startle and fear-conditioned responses. (A) The average accelerometer voltage of the startle response to repeated puffs of air is indistinguishable between WT and CRH KO mice. (B) Fear-conditioned freezing. The two genotypes exhibit freezing behavior for similar amounts of time before application of foot shock (Pre). Twenty-four h after 36 foot shocks (100-ms duration every 10 s), WT and CRH KO mice have no increase in freezing in a neutral chamber (Neutral) but exhibit a similar, significant 7-fold increase in conditioned freezing when placed in the original shock chamber (Post). In A–B, WT, closed symbols; CRH KO, open symbols.