Table 3.
Risk factors according to univariate survival analyses in the total population of patients (n = 231).
| Variable | Median (Quartile) | p-value§ | HR | 95%-CI of HR |
| Disease category + | - | < 0.001 | 0.266 | 0.139–0.508 |
| Sex (m/f) | - | 0.091 | 1.803 | 0.911–3.568 |
| Age (yrs) | 65.4 (57.1; 70.4) | 0.074 | 1.745 | 0.940–3.238 |
| BMI (kg/m2) | 31.6 (26.9; 38.2**) | 0.006 | 0.420 | 0.223–0.792 |
| Leukocytes (103/μL) | 8.6 (6.6*; 10.6*) | 0.002 | 2.745 | 1.414–5.332 |
| BE (mmol/L) | 3.70 (2.00; 5.50***) | 0.027 | 1.991 | 1.067–3.715 |
| FEV1 (L) | 1.03 (0.76; 1.59*) | < 0.001 | 0.267 | 0.131–0.544 |
| FEV1 (%pred) | 42.1 (31.9**; 63.5*) | 0.001 | 0.351 | 0.179–0.686 |
| IVC (L) | 1.84 (1.38; 2.56) | 0.112 | 0.617 | 0.338–1.125 |
| IVC (%pred) | 60.8 (45.9; 76.1*) | 0.205 | 0.665 | 0.352–1.255 |
| FEV/IVC (%) | 62.0 (47.0; 76.0) | 0.001 | 0.950 | 0.920–0.981 |
| SRI-RC | 62.5 (46.9*; 75.0**) | < 0.001 | 0.280 | 0.142–0.554 |
| SRI-PF | 50.0 (33.3*; 70.0*) | 0.002 | 0.379 | 0.198–0.724 |
| SRI-AS | 64.3 (53.6; 75.0) | 0.124 | 0.629 | 0.342–1.142 |
| SRI-SR | 75.0 (58.3**; 83.3*) | 0.002 | 0.381 | 0.202–0.718 |
| SRI-AX | 65.0 (45.0*; 80.0*) | 0.006 | 0.420 | 0.223–0.793 |
| SRI-PW | 61.1 (50.0**; 77.8) | 0.012 | 0.464 | 0.251–0.857 |
| SRI-SF | 56.3 (40.6*; 75.0*) | 0.002 | 0.374 | 0.198–0.705 |
| SRI-SS | 60.0 (49.7**; 74.9*) | < 0.001 | 0.262 | 0.129–0.530 |
Median values and quartiles are given for the total population, as values were not normally distributed due to the pooling of groups.+ COPD vs. non-COPD. § according to univariate survival analyses (log-rank) using the respective median value. Additionally, 25th and 75th percentiles were used. *p < 0.05; **p < 0.01; ***p < 0.001. Definition of abbreviations: HR = hazard ratio for survival; CI = Confidence interval; BMI = body-mass index; BE = base excess; FEV1 = forced expiratory volume in one second; IVC = inspiratory vital capacity; SRI = Severe Respiratory Insufficiency Questionnaire; RC = Respiratory Complaints; PF = Physical Functioning; AS = Attendant symptoms and Sleep; SR = Social Relationships; AX = Anxiety; WB = Psychological Well-being; SF = Social Functioning. SS = Summary Score.