Table 4.
Protein Kinase Dataset. Detailed SCOP classification for each protein domain in the Protein Kinase (PK) dataset, grouped according to Hanks' and Hunter's (HH) original classification scheme
| HH Cluster | Sub Cluster | Protein Domain | SCOP Classification Level | |||||
| Class | Fold | Superfamily | Family | Domain | Species | |||
| 1 | A | d1apme_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse |
| d1atpe_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse | ||
| d1bkxa_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse | ||
| d1fmoe_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse | ||
| d2cpke_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | mouse | ||
| B | d1cdka_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | pig | |
| d1cmke_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | pig | ||
| d1ctpe_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | pig | ||
| C | d1stce_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | cow | |
| d1ydre_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | cow | ||
| d1ydse_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | cow | ||
| d1ydte_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | cAMP-dep. PK, c.s. | cow | ||
| 2 | - | d1ptq_ | small | PK c.-r. domain | PK c.-r. domain | PK c.-r. domain | PK C-delta (PKCdelta) | mouse |
| d1ptr_ | small | PK c.-r. domain | PK c.-r. domain | PK c.-r. domain | PK C-delta (PKCdelta) | mouse | ||
| 3 | - | d1phk_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | γ-subunit glycogen Phk | rabbit |
| 4 | A | d1a06_ _ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Calmodulin-dep. PK | rat |
| B | d1cdma_ | α | EF Hand-like | EF-hand | Calmodulin-like | Calmodulin | cow | |
| d1cm1a_ | α | EF Hand-like | EF-hand | Calmodulin-like | Calmodulin | cow | ||
| d1cm4a_ | α | EF Hand-like | EF-hand | Calmodulin-like | Calmodulin | cow | ||
| 5 | A | d1lr4a_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Casein kinase-2, CK2 | maize |
| B | d1csn_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Casein kinase-1, CK1 | fission yeast | |
| d2csn_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Casein kinase-1, CK1 | fission yeast | ||
| 6 | - | d1aq1_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human |
| d1fina_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human | ||
| d1hck_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human | ||
| d1hcl_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human | ||
| d1jsua_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | Cyclin-dep. PK, CDK2 | human | ||
| 7 | A | d1ad5a1 | β | SH3-like barrel | SH3-domain | SH3-domain | Hemapoetic cell kinase Hck | human |
| d1ad5a2 | α + β | SH2-like | SH2 domain | SH2 domain | Hemopoetic cell kinase Hck | human | ||
| d1ad5a3 | α + β | PK-like | PK-like | PK c.s. (TK) | Hemopoetic cell kinase Hck | human | ||
| d1fmk_ 1 | β | SH3-like barrel | SH3-domain | SH3-domain | c-src protein TK | human | ||
| d1fmk_ 2 | α + β | SH2-like | SH2 domain | SH2 domain | c-src TK | human | ||
| d1fmk _3 | α + β | PK-like | PK-like | PK c.s. (TK) | c-src TK | human | ||
| d2hcka_1 | β | SH3-like barrel | SH3-domain | SH3-domain | Hemapoetic cell kinase Hck | human | ||
| d2hcka_2 | α + β | SH2-like | SH2 domain | SH2 domain | Hemopoetic cell kinase Hck | human | ||
| d2hcka_3 | α + β | PK-like | PK-like | PK c.s. (TK) | Haemopoetic cell kinase Hck | human | ||
| d2ptk _1 | β | SH3-like barrel | SH3-domain | SH3-domain | c-src protein TK | chicken | ||
| d2ptk_ 2 | α + β | SH2-like | SH2 domain | SH2 domain | c-src TK | chicken | ||
| d2ptk _3 | α + β | PK-like | PK-like | PK c.s. (TK) | c-src TK | chicken | ||
| B | d1aotf_ | α + β | SH2-like | SH2 domain | SH2 domain | TK Fyn | human | |
| d1blj_ | α + β | SH2-like | SH2 domain | SH2 domain | P55 Blk protein TK | mouse | ||
| d1csya_ | α + β | SH2-like | SH2 domain | SH2 domain | Syk TK | human | ||
| d1cwea_ | α + β | SH2-like | SH2 domain | SH2 domain | p56-lck TK | human | ||
| C | d1fgka_ | α + β | PK-like | PK-like | PK c.s. (TK) | Fibroblast growth factor receptor 1 | human | |
| d1ir3a_ | α + β | PK-like | PK-like | PK c.s. (TK) | Insulin receptor | human | ||
| d1irk_ | α + β | PK-like | PK-like | PK c.s. (TK) | Insulin receptor | human | ||
| d3lck_ | α + β | PK-like | PK-like | PK c.s. (TK) | Lymphocyte kinase (lck) | human | ||
| 8 | A | d1erk_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | MAP kinase Erk2 | rat |
| B | d1ian_ _ | α + β | PK-like | PK-like | PK c.s. (S/TK) | MAP kinase p38 | human | |
| d1p38__ | α + β | PK-like | PK-like | PK c.s. (S/TK) | MAP kinase p38 | mouse | ||
| d1wfc_ | α + β | PK-like | PK-like | PK c.s. (S/TK) | MAP kinase p38 | human | ||
| 9 | A | d1koa _1 | β | IG-like β-sandwich | IG | I set domains | Twitchin | nematode |
| d1ko_a 2 | α + β | PK-like | PK-like | PK c.s. (S/TK) | Twitchin, kinase domain | Caenorhabditis elegans | ||
| B | d1kob_a | α + β | PK-like | PK-like | PK c.s. (S/TK) | Twitchin, kinase domain | California sea hare | |
IG = Immunoglobulin, PhK = Tyrosine Phosphorylase Kinase, S/TK = Serine/Threonin Kinase, TK = Tyrosine Kinase, c.s. = catalytic subunit, c.-r. = cysteine-rich., dep. = dependent