Figure 3.

(A, B) Stacked contact maps for residues from complex structures of 4-helical bundle (A) and TNF-like cytokines (B) and their receptors. The aligned two-dimensional contact maps are shown in a three-dimensional space to illustrate their similarity. Only the residue positions from the interaction cores are shown. Columns correspond to residues from receptors, and rows, ligands. The shading of the contacts corresponds to the distance between residues, defined by the shortest distance between any two heavy atoms. The lighter colors reflect shorter distance. The aligned core map shows aligned positions and the colors indicate the distance averaged among aligned pairs from all five complexes.