Table III.
Parameter Estimates for Scheme 3+2′
| Partial charge | WT's rate at 0 mV | V2's rate at 0 mV | ||
|---|---|---|---|---|
| e0 | s−1 | s−1 | ||
| For S0↔ S1, S1↔ S2, and S2↔ S3 | ||||
| qa 1 = 0.47 | a 1(0) = 1650 (c = 1.3) | a 1(0) = 1450 (c) | ||
| qb 1 = −0.52 | b 1(0) = 450 (1/c) | b 1(0) = 450 (1/c) | ||
| qa 2 = 0.08 | a 2(0) = 4900 | a 2(0) = 4270 | ||
| qb 2 = −0.52 | b 2(0) = 960 | b 2(0) = 960 | ||
| qa 3 = 0.08 | a 3(0) = 7920 | a 3(0) = 6980 | ||
| qb 3 = −0.52 | b 3(0) = 1560 | b 3(0) = 1560 | ||
| For the transitions near the open state | ||||
| q αN-1 = 0.75 | αN-1(0) = 7000 | αN-1(0) = 3800 | ||
| q βN-1 = −0.30 | βN-1(0) = 340 | βN-1(0) = 19000 | ||
| q αN = 0.18 | αN(0) = 7000 | αN(0) = 3800 | ||
| q βN = −0.52 | βN(0) = 240 | βN(0) = 650 | ||
| qc = 0.2 | c(0) = 7 | c(0) = 17 | ||
| qd = 0.0 | d(0) = 600 | d(0) = 600 | ||
| qe 1 = 0.0 | e 1(0) = 230 | e 1(0) = 400 | ||
| qf 1 = 0.20 | f 1(0) = 3500 | f 1(0) = 3500 | ||
| qe 2 = 0.0 | e 2(0) = 600 | e 2(0) = 600 | ||
| qf 2 = 0.0 | f 2(0) = 7000 | f 2(0) = 7000 |
The parameter c reflects a small amount of cooperative interaction, which has been introduced into S0↔ S1, as shown in Scheme I.