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PCR-SSCP analysis of the 5′ noncoding regions of BCL-6 gene in paired serial biopsy specimens of FL (A) and transformed DLCL (B). Representative results obtained for PCR-amplified fragments from the E1.11 regions of BCL-6 gene in Cases 3–5 are shown. A positive control (P), represented by a tumor sample known to harbor BCL-6 mutations, as well as sample that was not denatured before electrophoresis (N) are shown. Arrows identify abnormally migrating bands.
