Table 1.

Summary of the BCL-6 Gene Rearrangement, PCR-SSCP Analysis of the BCL-6 5′ Noncoding Regions and Expression of the BCL-6 Protein in 12 Cases of Paired FL and Subsequent FL or DLCL Samples

Case	Sample	Date of biopsy	Histology	BCL-6 rearrangement		BCL-6 5′ Noncoding region				BCL-6 expression (%)
				XbaI	BamHI	E1.10	E1.11	E1.12	E1.13
1	A	1991	FL-II	G	G	WT	M	M	WT	100
	B	1992	DLCL	G	G	WT	M	WT	WT	100
2	A	1986	FL-II	G	G	WT	M	WT	WT	100
	B	1992	DLCL	G	G	WT	M	WT	WT	100
3	A	1989	FL-III	G	G	WT	M	WT	M	100
	B	1990	DLCL	G	G	WT	M	WT	M	100
4	A	1988	FL-III	G	G	WT	WT	WT	WT	100
	B	1989	DLCL	G	G	WT	WT	WT	WT	100
5	A	1985	FL-I	G	G	WT	M	WT	WT	100
	B	1988	DLCL	G	G	WT	M	WT	WT	20
6	A	1987	FL-I	G	G	WT	WT	WT	WT	100
	B	1988	DLCL	G	G	WT	M	M	WT	10
7	A	1983	FL-I	G	G	WT	WT	WT	WT	100
	B	1990	DLCL	G	G	M	M	WT	WT	10
8	A	1984	FL-I	G	G	WT	WT	WT	WT	100
	B	1986	DLCL	G	G	WT	WT	WT	WT	100
9	A	1989	FL-II	G	G	WT	WT	WT	WT	100
	B	1990	DLCL	G	G	WT	WT	WT	WT	100
10	A	1986	FL-I	G	G	WT	WT	WT	WT	ND
	B	1987	DLCL	G	G	WT	WT	WT	WT	ND
11	A	1998	FL-I	G	G	WT	M	WT	WT	100
	B	1999	FL-I	G	G	WT	M	WT	WT	100
12	A	1997	FL-II	G	G	WT	WT	WT	WT	100
	B	1999	FL-II	G	G	WT	WT	WT	WT	100

A, first biopsy sample; B, second biopsy sample; FL-I, follicular lymphoma—cytological grade I; FL-II, follicular lymphoma—cytological grade II; FL-III, follicular lymphoma—cytological grade III; DLCL, diffuse large cell lymphoma; G, germline configuration; M, mutations identified in PCR-SSCP fragments; ND, not detected; WT, wild-type.