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. Author manuscript; available in PMC: 2008 Jan 31.
Published in final edited form as: Drug Metab Dispos. 2006 Feb 7;34(5):880–886. doi: 10.1124/dmd.105.008672

TABLE 3.

Specific P450 contents (picomoles per milligram microsomal protein) in human small intestinal microsomes (HIM)

P450 1A1 2A6 2B6 2C9 2C19 2D6 2E1 2J2 3A4 3A5
Mean 5.6 BLD BLD 8.4 1.0 0.5 BLD 0.9 43 16
(individuals)                    
n 3 31 31 31 31 29 31 31 31 11
Range 3.6–7.7     2.9–27 <0.6–3.9 <0.2–1.4   <0.2–3.1 8.8–150 4.9–25
Mean ± S.D.a BLD BLD BLD 11 ± 0.5 2.1 ± 0.1 0.7 ± 0.01 BLD 1.0 ± 0.1 58 ± 1.0 16 ± 0.3
(pooled HIM)b                    
LOD 1.5 2.0 1.3 2.0 0.6 0.2 0.2 0.2 8 4

BLD, below limit of detection; LOD, limit of detection (picomoles per milligram).

a

Values denote the mean ± S.D. of triplicate measurements.

b

The pooled sample consisted of 31 (for P450s 1A1, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4) or 11 (for CYP3A5) individual preparations.