Table II.
Properties of Wild-Type and Mutant Kv1.4 Currents*
| Wild type | V[556,558]I | |||
|---|---|---|---|---|
| G/V relation | ||||
| V0.5 (mV) | −60.6 ± 3.0 | −48.4 ± 2.1 | ||
| S (mV) | 23.2 ± 0.8 | 30.1 ± 3.3 | ||
| (n = 7) | (n = 4) | |||
| Prepulse inactivation | ||||
| V0.5 (mV) | −55.7 ± 1.2 | −44.6 ± 2.7 | ||
| S (mV) | 3.4 ± 0.7 | 3.6 ± 0.5 | ||
| (n = 3) | (n = 3) | |||
| Onset of inactivation | ||||
| τ-1 (ms) | 47.1 ± 12.9 | 54.8 ± 20.9 | ||
| τ-2 (ms) | 159 ± 55 | 233 ± 58 | ||
| W-1 | 0.75 ± 0.10 | 0.86 ± 0.03 | ||
| W-2 | 0.24 ± 0.11 | 0.13 ± 0.02 | ||
| W-ss | 0.02 ± 0.01 | 0.01 ± 0.01 | ||
| (n = 4) | (n = 5) | |||
| Recovery from inactivation τ (ms) | ||||
| 1719 ± 546 | 9400 ± 809 | |||
| (n = 4) | (n = 3) | |||
| Deactivation τ (ms) | 1.1 ± 0.2 | 10.8 ± 1.6 | ||
| (n = 4) | (n = 3) | |||
| Block by 4-AP percent inhibition | 65.9 ± 16.0 | 0.0 ± 0.2 | ||
| (n = 5) | (n = 3) |
*
Analysis, abbreviations, and symbols are as described in Table I.