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. 2007 Dec 27;5(12):e340. doi: 10.1371/journal.pbio.0050340

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Initially, X and AA expression are out of balance in both males and females.

(B) The combination of increased X chromosome expression and X inactivation in females balances expression later in development.