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. 1999 Jan 1;113(1):7–16. doi: 10.1085/jgp.113.1.7

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Effect of lidocaine on the voltage dependence of site 1304 accessibility. The rate of MTS-ET modification of F1304C was measured at a variety of voltages, as shown in A. Excised, inside-out patches underwent a series of 300-ms depolarizations: 200 ms to achieve steady state fast inactivation, followed by 50 ms for exposure to 8.0 μM MTS-ET, and a final 50-ms period after exposure to insure complete washout of MTS-ET before repolarization. After each 300-ms depolarization, the patch was maintained at −120 mV for enough time to insure complete recovery (2–8 s, depending on the conditioning voltage) before assaying macroscopic current with a test pulse to −20 mV. Modification rates are shown in B when the experiments were conducted in the absence (•) and presence (○) of 1.0 mM lidocaine. (On average, n = 6, n = at least 3 for each point.)