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Pretreatment of S. aureus biofilms with DNase I renders them sensitive to killing by CPC. (A) S. aureus SH1000 and S. epidermidis NJ9709 biofilms grown in microtiter plates were treated with 0.3% CPC (for S. aureus) or 0.1% CPC (for S. epidermidis) for 5 min. Values show mean numbers of surviving CFU/well for duplicate wells. Black bars show CFU/well values for biofilms pretreated with 100 μg/ml of DNase I for 10 min prior to addition of the CPC.
