TABLE 2.
Predicted behavior of the quorum-sensing circuits of gram-negative plant and human pathogensa
| Pathogen | LuxI/LuxR homolog | Cooperative DNA binding | Feedbackb | Predicted response | Reference(s) |
|---|---|---|---|---|---|
| Agrobacterium tumefaciens | TraR/TraI | No | +, TraR/TraI | Bistable | 20, 62 |
| Burkholderia cepacia | CepR/CepI | Yes | +, CepI | Bistable | 58 |
| Erwinia chrysanthemi | ExpR/ExpI | No | +, ExpI | Threshold | 8, 42 |
| Pantoea stewartii | EsaR/EsaI | No | −, EsaR | Threshold | 38 |
| Pseudomonas aeruginosa | LasR/LasI | No | +, LasI | Threshold | 45 |
a
Based on the experimentally observed cooperativity of DNA binding and the feedback on quorum-sensing elements.
b
Plus and minus signs denote positive and negative feedback, respectively.