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. 1999 Feb 1;113(2):215–228. doi: 10.1085/jgp.113.2.215

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Relationship between [Ca²⁺]_SR and Ca²⁺ sparks. (A) Relationship between time after a 3-s caffeine application and amplitude (□) and frequency (•) for Ca²⁺ sparks. After the caffeine application, Ca²⁺ sparks ceased, and then recovered as the SR refilled. (B) Relationship between fractional [Ca²⁺]_SR and spark frequency (•) and amplitude (□) determined as described in the text. Images were acquired as in Fig. 2, and the amplitude and frequency of Ca²⁺ sparks were normalized to values before the application of caffeine (n = 4 cells).