FIG. 4.

Transgenic rescue of the nm1054 primary ciliary dyskinesia. (A and B) Sections of BAC 528N15 transgenic B6129F1 nm1054 testis (A) and maxillary sinus and turbinates (B), which are indistinguishable from the wild type. Sections were stained with hematoxylin and eosin. (C) Schematic map of overlapping BAC clones spanning the nm1054 deletion interval. The thick black line (bottom) represents the deleted interval on chromosome 1. Deleted genes are shown as gray boxes, with the direction of transcription indicated by a small arrow above each gene. Individual CITB and RPCI-22 BAC clones are represented as thin black lines and identified by clone identification numbers. BAC CITB 528N15 contains only Pcdp1.