FIG. 4.

Inflammatory lesions in the gastric mucosa of κB-lacZ mice in response to Helicobacter infection. Mice were either administered broth alone (Naive) or challenged with bacterial suspensions of H. felis, H. pylori 245 (Hp245), or H. pylori SS1 (HpSS1). Animals were sacrificed at day 1 (A), 30 (B), or 135 (C) postchallenge. Tissue sections from the mice were assessed for PMN and lymphocyte/plasma cell infiltration in the lamina propria of the antrum (A) and fundus (F), lymphoid aggregates and gland abscesses (adenitis), parietal cell atrophy, and submucosal inflammation. Each datum point corresponds to the scores of an individual animal, whereas the horizontal bars represent the mean score per group (four to six animals per group). Statistically significant differences between Helicobacter-infected and naive animals are shown as follows: *, P < 0.05; **, P < 0.01; ***, P < 0.005.