TABLE 1.

Spleen characteristics at different stages of tularemia

Mice	Organ wt (mg)a	Gross anatomy	Histopathology
Uninfected controls (n = 4)	72.5 ± 5	Normal	Normal
Moribund (n = 5)	120 ± 12.2b	Pale, friable, visibly enlarged	Lymphocyte depletion, necrosis
Survivors
Day 7 (n = 6)	185 ± 48.4c	No color variation, visibly enlarged	Erythrocytes in sinusoids, megakaryocytes
Day 50 (n = 3)	186.6 ± 30.5c	No color variation, visibly enlarged	Erythrocytes in sinusoids, megakaryocytes

^aAverage weights ± standard deviations.

^bP < 0.05 compared to uninfected controls; Mann-Whitney U test.

^cP < 0.01 compared to uninfected controls; Mann-Whitney U test.