TABLE 2.

Lung features at different disease stages of tularemia

Mice	Organ wt (mg)a	Gross anatomy	Histopathology
Uninfected controls (n = 4)	175 ± 17.3	Normal	Normal
Moribund (n = 5)	308 ± 43.8b	Color variation, visibly enlarged	Diffuse edema, neutrophils and necrosis
Survivors
Day 7 (n = 6)	226.6 ± 64.5	Normal	Neutrophil and some lymphocyte infiltration, no fibrin deposits or edema
Day 50 (n = 3)	246.6 ± 64.2	Normal	Prominent lymphoid aggregates

^aAverage weights ± standard deviations.

^bP < 0.05 compared to uninfected controls; Mann-Whitney U test.