FIG. 1.

Alignment of Ndx2 and other ADPRases. Shown is the amino acid sequence alignment of Ndx2 and several ADPRase-I and ADPRase-II enzymes. The secondary structural elements of Ndx2 are shown above the sequence. Sequences shown here are as follows: T. thermophilus HB8 (Ndx2, Ndx4, BAC67698), E. coli (ORF186 [NP_417856], ORF209 [NP_417506]), T4 bacteriophage (NudE.1 [NP_049737]), M. tuberculosis (MtADPRase [NP_216216]), and Synechocystis sp. strain PCC 6803 (Slr1134 [NP_440605], Sll1054 [NP_439968]). Stars indicate residues that are conserved in ADPRase-I enzymes. The structural alignment for the proteins of known structure was calculated with MATRAS (13), and sequence alignment was prepared with ClustalW (31).