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Transmission electron microscopy of human IVOC infected with ICC223. A. ICC223 efficiently colonizes the gut mucosa. B. Typical A/E lesion with intimate bacterial attachment and effacement of brush border microvilli; increased electron density at the site of bacterial attachment (representing accumulated actin) is not apparent. C. ICC223 expressing a TccP A/E lesion, showing increased electron density in the epithelium at the site of attachment. Bars, 2 μm (A) or 0.5 μm (B and C).
