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Generation of M. tuberculosis smc mutant. Genomic DNA from M. tuberculosis wild-type (lane 1) and smc mutant (lane 2) strains was digested with BamHI and probed with a 935-bp NdeI gene fragment containing the 5′ flanking region of the smc gene. The presence of a single 4.3-kbp fragment instead of an 11.1-kbp fragment as seen in the parental strain demonstrates successful deletion of smc coding sequences.
