TABLE 3.

Significant covariates of cytokine levels in cervical mucus^a

Cytokine	Odds ratio (95% CI) fora
	Continuous variablesb		Categorical variablesc
	Age at first intercourse	Days since last intercourse	Current yeast infection	>5 WBCs/HPFd on wet-mount examination	Cigarette smoking within last 24 he
Proinflammatory
IL-1β					0.33* (0.12, 0.94)
IL-6					0.33* (0.12, 0.93)
IL-8	1.52** (1.13, 2.04)			4.82* (1.21, 19.2)
Immunoregulatory
IFN-γ			7.52* (1.36, 41.5)		0.33* (0.11, 0.93)
IL-2
IL-4
IL-5		0.99** (0.98, 1.00)	9.80** (1.69, 56.8)
IL-10					0.34* (0.12, 0.94)
IL-12			6.02* (1.23, 29.6)
IL-13				3.85* (1.13, 13.2)

^aProportional odds ratios (95% confidence intervals [CI]) of having higher quartiles of cytokine levels in a multinomial logistic regression model controlling for the variables shown as well as for race and days since LMP. *, P ≤ 0.05; **, P ≤ 0.01.

^bFor continuous variables, the odds ratio represents the change in odds of cytokines being in the higher quartile group versus the comparison group, associated with a 1-U change in the independent variable (e.g., 1 day for the variable days since last intercourse).

^cFor categorical variables, the odds ratio represents the change in the odds of cytokines being in the higher quartile group versus the comparison group, associated with the independent variable.

^dWBC/HPF, white blood cells per high-power field.

^ePatient report of smoking of one or more cigarettes within 24 h preceding study visit.