TABLE 4.
Cytokine levels in incident and persistent HPV infections compared with negative control subjects
| Cytokine | Negative control groupa (n = 34)
|
Incident HPV infection groupb (n = 15)
|
Persistent HPV infection groupc (n = 18)
|
|||
|---|---|---|---|---|---|---|
| Median cytokine level, pg/ml (IQR)d | No. of samples in which cytokine was undetectablee | Median cytokine level, pg/ml (IQR)d | No. of samples in which cytokine was undetectablee | Median cytokine level, pg/ml (IQR)d | No. of samples in which cytokine was undetectablee | |
| Proinflammatory | ||||||
| IL-1β | 263 (117, 609) | 2 | 171 (102, 566) | 0 | 138 (85, 446) | 0 |
| IL-6 | 3,117 (1,111, 4,957) | 0 | 1,699 (977, 2,315) | 0 | 2,779 (1,474, 4,056) | 0 |
| IL-8 | 13,338 (6,294, 24,165) | 1 | 16,666 (5,783, 28,439) | 0 | 9,838 (6,140, 26,571) | 0 |
| Immunoregulatory | ||||||
| IFN-γ | 5 (2, 9) | 0 | 3 (2, 4) | 1 | 3 (1, 7) | 0 |
| IL-2 | 29 (15, 39) | 0 | 19 (12, 35) | 0 | 29 (17, 39) | 0 |
| IL-4 | 11 (5, 26) | 9 | 8 (5, 17) | 2 | 13 (10, 17) | 3 |
| IL-5 | 6 (2, 9) | 0 | 4 (2, 7) | 1 | 5 (3, 7) | 0 |
| IL-10 | 43 (15, 81) | 0 | 46 (29, 73) | 0 | 31 (21, 43) | 0 |
| IL-12 | 121 (71, 301) | 0 | 95 (52, 123) | 0 | 93 (58, 160) | 0 |
| IL-13 | 44 (20, 91) | 20 | 13 (5, 30) | 8 | 19 (13, 57) | 11 |
a
HPV negative at the cytokine test visit and all prior study visits.
b
HPV positive at the cytokine test visit but HPV negative at all study visits prior to the cytokine test visit.
c
HPV positive (same type) at both the cytokine test visit and the study visit 4 months prior.
d
Median (interquartile range [IQR]) cytokine levels (picograms per milliliter) of samples in which cytokine was detected.
e
Number of samples in which cytokine was undetectable (included as lowest rank in Wilcoxon rank sum test).