TABLE 1.

Relationship between RWJ-54428 MIC and fT_>MIC required to achieve various degrees of antibacterial effects in vivo

Organism	MIC (μg/ml)	% fT>MIC of RWJ-54428 required to achieve:
		Static effect	1-log drop	2-log drop	Emax
MRSA COL	1.0	14	20	NAa	36
MRSA 076	1.0	16	23	28	32
MRSA 602	0.5	17	20	NA	24
MRSA 604	0.5	20	23	28	30
MRSA 609	0.5	16	18	21	22
S. pneumoniae ATCC 49619	0.03	18	21	23	28
S. pneumoniae SP 019b	0.5	16	22	28	30
E. faecalis ATCC 29212	0.06	30	48	NA	60
E. faecalis EFS 007	0.125	46	56	NA	60

^aNA, not applicable.

^bPenicillin-resistant strain.