TABLE 2.
MICs of all agents against the 14 strains tested by time-kill analyses
| Drug | MIC(s) (μg/ml)a for:
|
||||||
|---|---|---|---|---|---|---|---|
| Bacteroides fragilis | Bacteroides thetaiotaomicron | Prevotella intermedia | Finegoldia magna | Fusobacterium nucleatum | Clostridium perfringens | Clostridium difficile | |
| Doripenem | 0.25 | 0.25, 0.5 | 0.06, 0.125 | 0.06 | 0.016 | 0.03 | 1.0 |
| Imipenem | 0.06 | 0.25 | 0.03, 0.06 | 0.06, 0.125 | 0.016 | 0.06 | 4.0 |
| Ertapenem | 0.25 | 0.5, 1.0 | 0.03, 0.125 | 0.03, 0.06 | 0.008 | 0.125 | 4.0 |
| Meropenem | 0.125 | 0.25, 0.5 | 0.03, 0.25 | 0.06 | 0.008 | 0.03 | 1.0, 2.0 |
| Piperacillin-tazobactam | 0.125, 0.25 | 8.0, 16.0 | NTb | 0.125, 0.25 | NTb | 0.25 | 8.0 |
| Amoxicillin-clavulanate | 2.0 | 2.0 | 0.06, 0.25 | 0.25 | 0.06, 0.25 | 0.06, 0.125 | 0.5, 1.0 |
| Ceftriaxone | 0.25, 0.5 | NTc | 0.125, 8.0 | 8.0, 16.0 | 0.125, 0.25 | 2.0, 4.0 | NTc |
| Clindamycin | 0.5 | 2.0, 4.0 | 0.016 | 0.25, 4.0 | 0.06, 0.125 | 0.125, 2.0 | 8.0 |
| Metronidazole | 2.0 | 1.0 | 0.5, 1.0 | 1.0, 2.0 | 0.016, 0.25 | 2.0 | 0.5 |
a
Two strains of each species were tested. Intraspecies MICs which differed from one another are separated with a comma. NT, not tested.
b
This strain had an MIC of ≤0.004 μg/ml.
c
This strain had an MIC of >32.0 μg/ml.