TABLE 3.

Results of time-kill assays at the various time periods tested and at different drug concentrations

Drug and concn	No. of strains killed by indicated %a at:
	6 h			12 h			24 h			48 h
	90%	99%	99.9%	90%	99%	99.9%	90%	99%	99.9%	90%	99%	99.9%
Doripenem
4× MIC	12	11	8	12	10	10	14	12	10	14	14	11
2× MIC	12	10	8	12	10	10	14	12	10	14	14	11
MIC	12	10	8	12	10	8	14	11	9	14	14	9
Imipenem
4× MIC	12	10	9	13	10	9	14	13	10	14	14	11
2× MIC	12	10	9	13	10	9	14	13	10	14	14	11
MIC	12	10	9	13	10	9	14	13	10	14	14	10
Meropenem
4× MIC	12	10	7	12	10	9	14	12	10	14	14	10
2× MIC	12	10	7	12	10	9	14	12	10	14	14	10
MIC	12	9	3	12	10	7	14	11	6	13	10	5
Ertapenem
4× MIC	12	9	8	13	10	10	14	12	10	14	14	11
2× MIC	12	9	7	13	10	9	14	12	10	14	14	11
MIC	12	9	6	13	10	7	14	12	9	12	10	7
Piperacillin-tazobactamb
4× MIC	8	6	3	8	7	5	10	8	6	10	10	6
2× MIC	7	3	3	8	5	5	10	7	5	10	9	3
MIC	6	2	2	8	5	3	10	6	4	10	6	2
Amoxicillin-clavulanate
4× MIC	11	9	6	14	10	8	14	14	11	12	12	10
2× MIC	11	9	6	14	10	8	14	13	10	11	11	9
MIC	11	8	5	13	10	7	14	13	9	10	9	6
Ceftriaxonec
4× MIC	8	7	4	9	8	7	10	10	8	9	9	7
2× MIC	8	7	4	9	8	5	10	9	8	8	8	6
MIC	8	4	3	7	6	3	7	6	5	5	4	2
Clindamycin
4× MIC	10	3	0	12	5	2	14	14	7	14	14	12
2× MIC	8	3	0	12	5	1	14	13	7	13	13	10
MIC	8	3	0	12	5	0	14	12	4	12	9	5
Metronidazole
4× MIC	14	14	14	14	14	14	14	14	14	14	14	14
2× MIC	14	12	11	14	14	13	14	14	13	14	13	13
MIC	13	10	4	14	12	8	13	12	11	11	10	10

^aKilling by 99.9% indicates bactericidal activity.

^bFour strains with MICs of ≤0.004 μg/ml were not tested.

^cFour strains with MICs of >32 μg/ml were not tested.