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Comparison of CD4+ T-cell reactivity to HBcAg in patients receiving ADV or the placebo. *, there was a significant increase in the frequencies of IFN-γ-producing CD4+ T cells at TW16 compared to baseline values for ADV-treated patients (P = 0.03). **, at TW40 and TW48, patients receiving ADV had significantly higher frequencies of IFN-γ-producing CD4+ T cells than did patients receiving placebos (P = 0.03). The bars represent means ± SEMs.
