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. 2007 Nov 5;52(1):312–320. doi: 10.1128/AAC.00467-07

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FIG.4. — Time course analysis of serum ALT levels, virological parameters, and the frequency of IFN-γ-producing CD4⁺ T cells during the study period. (a and b) For two representative patients from group 1, an increased frequency of IFN-γ-producing CD4⁺ T cells preceded or coincided with HBeAg loss, without ALT flare. (c) A representative patient from group, who received ADV treatment, but had moderate reduction in viremia, remained HBeAg⁺ and showed no increase in the frequency of virus-specific, IFN-γ-producing T cells. IFN_γ, IFN-γ; ND, not determined.

FIG.4. — Time course analysis of serum ALT levels, virological parameters, and the frequency of IFN-γ-producing CD4⁺ T cells during the study period. (a and b) For two representative patients from group 1, an increased frequency of IFN-γ-producing CD4⁺ T cells preceded or coincided with HBeAg loss, without ALT flare. (c) A representative patient from group, who received ADV treatment, but had moderate reduction in viremia, remained HBeAg⁺ and showed no increase in the frequency of virus-specific, IFN-γ-producing T cells. IFN_γ, IFN-γ; ND, not determined.