TABLE 3.
In vitro IFN-γ production after stimulation with rHBcAg
| Group | IFN-γ production indexa at:
|
||||||
|---|---|---|---|---|---|---|---|
| BL | TW4 | TW8 | TW16 | TW24 | TW40 | TW48 | |
| 1 | 99.2 ± 29.3 | 58.9 ± 67.2 | 184.3 ± 308.3 | 63.9 ± 52.7 | 26.3 ± 32.2 | 61.5 ± 73.2 | 18.0 ± 26.7 |
| 2 | 26.2 ± 53.6 | 33.8 ± 58.8 | 7.5 ± 11.9 | 30.0 ± 55.9 | 52.0 ± 48.2 | 15.7 ± 6.8 | 37.8 ± 51.6 |
| 3 | 20.3 ± 5.0 | 2.3 ± 2.2 | 17.0 ± 20.3 | 8.8 ± 8.5 | 22.5 ± 17.6 | 14.5 ± 8.8 | 7.1 ± 7.3 |
a
The IFN-γ production index was calculated at each time point by dividing the mean pg/ml IFN-γ production of four replicates of HBcAg-stimulated PBMC by that of the control cultures (PBMC incubated in medium only). Group 1 patients had significantly higher IFN-γ production values at baseline compared to those of group 3 (P = 0.05), but not to those of group 2 (P = 0.1). All data are shown as means ± standard deviations.