TABLE 1.
S. pneumoniae isolation dates, levofloxacin MICs, and genotype
| Patient | Day of study | Visitb | MEF culturea
|
Nasopharynx culture
|
||||
|---|---|---|---|---|---|---|---|---|
| Levofloxacin MIC (μg/ml) | PFGE type | Serotype | Levofloxacin MIC (μg/ml) | PFGE type | Serotype | |||
| 1 | 1 | PT | 0.5 | A | 6A | 0.5 | A | 6A |
| 5 | OT | NAc | —d | 1 | A | 6A | ||
| 24 | EOS | NA | — | 0.5 | A | 6A | ||
| 39 | UNS | NA | — | 0.5 | A | 6A | ||
| 2 | 1 | PT | 1 | W | 19A | 0.5 | B | NTe |
| 5 | OT | NA | — | 0.5 | C | NT | ||
| 15 | EOT | NA | — | 0.5 | B | NT | ||
| 19 | EOS | NA | — | 1 | D | 9V | ||
| 3 | 1 | PT | 0.5 | E | 23F | 0.5 | E | 23F |
| 4 | OT | NA | — | 0.5 | E | 23F | ||
| 15 | EOT | NA | — | 0.5 | E | 23F | ||
| 25 | EOS | NA | — | 0.5 | E | 23F | ||
| 4 | 1 | PT | 1 | F | 19F | 1 | F | 19F |
| 6 | OT | 1 | F | 19F | 1 | F | 19F | |
| 13 | EOT | NA | — | 1 | F | 19F | ||
| 21 | EOS | NA | — | 0.5 | G | NT | ||
| 35 | UNS | NA | — | 1 | F | 19F | ||
| 5 | 1 | PT | 0.5 | H | 6B | NA | — | |
| 5 | OT | NA | — | NA | — | |||
| 25 | EOS | NA | — | 0.5 | H | 6B | ||
| 37 | UNS | 0.5 | H | 6B | NA | — | ||
| 6 | 1 | PT | 1 (right) | I | 14 | 1 | J | 19F |
| 1 (left) | I | 14 | NA | — | ||||
| 13 | EOT | NA | — | 1 | I | 14 | ||
| 18 | EOS | NA | — | 0.5 | K | 6B | ||
| 7 | 1 | PT | 0.5 | L | 6A | 0.5 | L | 6A |
| 23 | EOS | NA | — | 1 | M | NT | ||
| 8 | 1 | PT | 0.5 | N | 23F | 1 | N | 23F |
| 5 | OT | NA | — | 1 | N | 23F | ||
| 12 | EOT | NA | — | 1 | N | 23F | ||
| 9 | 1 | PT | 1 (right) | O | 15A | 0.5 | O | 15A |
| 1 | 1 (left) | O | 15A | NA | — | |||
| 5 | OT | NA | — | 1 | O | 15A | ||
| 12 | EOT | NA | — | 1 | O | 15A | ||
| 23 | EOS | NA | — | 1 | O | 15A | ||
| 40 | UNS | NA | — | 1 | O | 15A | ||
| 10 | 1 | PT | 0.5 (right) | O1f | 19F | 1 | O2e | 19F |
| 1 (left) | O2f | 19F | ||||||
| 13 | EOT | NA | — | 1 | P | 11A | ||
| 21 | EOS | NA | — | 1 | O1f | 19F | ||
| 42 | UNS | NA | — | 0.5 | O1f | 19F | ||
| 11 | 1 | PT | 1 | Q | 17F | 1 | Q | 17F |
| 14 | EOT | NA | — | 1 | R | 15B | ||
| 21 | EOS | NA | — | 0.5 | S | 10A | ||
| 12 | 1 | PT | 1 | T | 19F | 1 | T1 | 19F |
| 12 | EOT | 0.5 | U | 4 | 1 | U | 4 | |
| 41 | UNS | NA | — | 0.5 | V | 15B | ||
a
Some patients had bilateral AOM, and MEF was removed from both left and right ears.
b
PT, pretreatment visit; UNS, unscheduled visit.
c
NA, not applicable since no specimen was obtained.
d
—, no PFGE data were available because S. pneumoniae was not isolated during that visit.
e
NT, nontypeable as S. pneumoniae because cultures did not react to Omni-sera.
f
PFGE types O1 and O2 are variants (1- to 2-band difference) of PFGE type O.