TABLE 5.

Activities of MTA analogs as substrates for Trypanosoma brucei brucei MTA-Pase

Compound group and no.a	Substrate	% of control activity
		With 50 mM PO4−	Without PO4−
Purine-modified analogs
IIb	2-Fluoro-HETA	148b	106b
VIIa	MTA	100c	100d
Ib	HETA	96	100
V	HET-RV	61	70
VI	Etheno-HETA	56	62
Ic	HET-FPR	42	60
IIa	2-Amino-HETA	29b	18b
Ie	HETN	11	4
Id	HET-MPR	2	25
Ia	HETI	0	0
IIIb	MTT	0	0
IIIa	HETT	0	0
	HETT + MTAe	99	2
Ribose-modified analogs
IXa	2′-Deoxy-HETA	100	81
VIIg	CMTA	84f	34f
VIIb	ETA	76.2f	26.9f
VIIc	MFETA	75.3f	29.3f
VIIe	HPTA	72.5f	27.4f
VIId	PTA	57.5f	26.0f
XII	HET-EMA	56	78
VIIf	MFPTA	47.5f	31.3f
VIIj	APTA	46	60
X	2′, 3′-seco-HETA	44	0
IXb	3′-Deoxy-HETA	39.4	37.8
IXc	2′, 3′-Dideoxy-HETA	17	18
VIII	MAA	4	0

^aNovel HETA analogs are distinguished in boldface.

^bData are from reference 3.

^c20.86 nmol/mg protein/h.

^d7.67 nmol/mg protein/h.

^eEquimolar (200 μM) concentrations of HETT and MTA.

^fData are from reference 8.