TABLE 2.
Histopathological evaluation of uninfected mice treated with AmBi or Anfo
| Treatment group | No. of mice with minimal renal tubular regeneration/ no. of mice in treatment group | No. of mice with renal tubular regeneration with concurrent degeneration and/or necrosis/no. of mice in treatment group | No. of mice with renal tubular regeneration with concurrent degeneration and/or necrosis classified as:
|
No. of mice with pulmonary arteriopathy/no. of mice in treatment group | |
|---|---|---|---|---|---|
| Minimal | Mild | ||||
| Control D5W | 0/6 | 0/6 | 0/6 | ||
| Anfo at: | |||||
| 0.5 mg/kg | 0/5 | 1/5 | 1 | 0/5 | |
| 1.0 mg/kg | 2/5 | 2/5 | 2 | 1/5 | |
| 5.0 mg/kg | 0/5a | 5/5b | 0 | 5c | 4/5d,e |
| AmBi at: | |||||
| 1.0 mg/kg | 1/5 | 2/5 | 2 | 1/5 | |
| 5.0 mg/kg | 2/5a | 2/5b | 2 | 0c | 1/5d |
| 25 mg/kg | 3/5 | 1/5 | 1 | 0/5e | |
a
P = 0.444 for Anfo at 5.0 mg/kg versus AmBi at 5.0 mg/kg for minimal tubular regeneration; two-tailed Fisher's exact test.
b
P = 0.167 for Anfo at 5.0 mg/kg versus AmBi at 5.0 mg/kg for tubular regeneration with concurrent degeneration; two-tailed Fisher's exact test.
c
P = 0.008 for Anfo at 5.0 mg/kg versus AmBi at 5.0 mg/kg for tubular regeneration with concurrent degeneration and/or mild necrosis; two-tailed Fisher's exact test.
d
P = 0.206 for Anfo at 5.0 mg/kg versus AmBi at 5.0 mg/kg for pulmonary arteriopathy; two-tailed Fisher's exact test.
e
P = 0.048 or Anfo at 5.0 mg/kg versus AmBi at 25.0 mg/kg for pulmonary arteriopathy; two-tailed Fisher's exact test.