FIG. 2.

Different concentration-time profiles for cefdinir in plasma (•) and in blister fluid (♦) after single doses of 300 mg (a) and 600 mg (b) (adapted from reference 85 with permission). The simultaneous blister fluid/plasma concentration ratios were <1 at time points of peak in plasma, while they were >1 after the time points of peak in blister fluid. AUC ratios of blister fluid/plasma were 86.3% and 92.4%, respectively. The ratio of AUC is a better parameter to represent tissue penetration of antibiotics.