TABLE 2.
Physical and chemical properties of the antibiotics investigated
| Antibiotic | Protein binding (%) | PC (log) | Mol wt | Ka | Referencesb |
|---|---|---|---|---|---|
| Amoxicillin | 20 | 0.614 | 365.41 | 0.82 | 70a, S |
| Cefdinir | 60-73 | −0.725 | 395.42 | 0.39 | 69, S |
| Meropenem | 2 | −0.6 | 383.46 | 0.56 | 70a, M |
| Azithromycin | 7.1-50 | 3.329 | 748.98 | 1.36 | 70a, S |
| Clarithromycin | 80 | 3.159 | 747.95 | 1.32 | 70a, S |
| Cethromycin | 90 | 5.24 | 765.93 | 1.76 | 65, S |
| Telithromycin | 70 | 5.093 | 812 | 1.72 | 2, S |
| Ciprofloxacin | 30 | 1.308 | 331.34 | 0.97 | 70a, S |
| Clinafloxacin | 2-7 | 1.63 | 365.79 | 1.03 | 12, S |
| Garenoxacin | 75 | 1.615 | 426.41 | 1.02 | 42, S |
| Gatifloxacin | 20 | 1.586 | 375.39 | 1.02 | 69, S |
| Levofloxacin | 30-40 | 1.485 | 361.37 | 1.00 | 70a, S |
| Lomefloxacin | 10 | 2.334 | 351.35 | 1.18 | 12, S |
| Moxifloxacin | 39-52 | 1.974 | 401.43 | 1.10 | 69, S |
| Pefloxacin | 25 | 2.164 | 333.36 | 1.15 | 70a, S |
| Rufloxacin | 60 | 1.894 | 363.41 | 1.09 | 12, S |
| Sparfloxacin | 40 | 2.866 | 392.4 | 1.29 | 12, S |
| Trovafloxacin | 87 | 1.566 | 416.35 | 1.01 | 12, S |
| Grepafloxacin | 50 | 2.261 | 359.39 | 1.17 | 12, S |
| Pyrazinamide | 50 | −0.368 | 123.11 | 0.66 | 70a, S |
| Ethionamide | 30 | 1.220 | 166.24 | 0.98 | 70a, S |
| Linezolid | 31 | −0.923 | 337.35 | 0.50 | 69, S |
| Itraconazole | 99.8 | 3.291 | 705.63 | 1.35 | 70a, S |
| Tigecycline | 79-89 | 2.09 | 585.65 | 1.11 | 23, M |
| Rifampin | 80 | 0.486 | 822.94 | 0.76 | 70a, S |
| Ethambutol | 10-40 | −0.053 | 204.31 | 0.71 | 70a, S |
| Isoniazid | 0 | −0.887 | 137.14 | 0.55 | 70a, S |
| Rifapentine | 97.7 | 1.981 | 877.03 | 1.07 | 55, S |
a
Constant K = 0.96 + 0.091·ln (PC·MW−1/2).
b
S, SciFinder Scholar database (American Chemical Society; 2004); M, MDL quantitative structure-activity relationship (Elsevier Science, Inc.; 2004).