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Representative concentration-effect curves of the metabolic activity of an A. fumigatus isolate (nongerminated [▵] and germinated [▿] conidia) in the presence of increasing concentrations of caspofungin, micafungin, and anidulafungin. For caspofungin and anidulafungin, the curves were generated with the bell-shaped model, and for micafungin, the curves were generated with the Emax model. The parameters calculated by the models, as well as the microscopically defined MECs, are presented.
