TABLE 1.
MEC values for germinated and nongerminated Aspergillus conidia
| Species (no. of strains) | Conidial state | Median (range) MEC (μg/ml)
|
||
|---|---|---|---|---|
| Caspofungina | Micafungina | Anidulafungina | ||
| A. fumigatus (11) | Nongerminated | 1 (0.5-1) | 0.06 (0.06-0.12) | 0.03 (0.015-0.03) |
| Germinated | 1 (1-1) | 0.25 (0.12-0.25) | 0.12 (0.12-0.25) | |
| Log2 of ratiob | 0 (0-1) | 1 (1-2)c | 2 (2-3)c | |
| A. terreus (8) | Nongerminated | 0.5 (0.5-1) | 0.12 (0.06-0.12) | 0.03 (0.015-0.03) |
| Germinated | 1 (1-2) | 0.25 (0.12-0.25) | 0.25 (0.25-0.5) | |
| Log2 of ratio | 1 (0-1)c | 1 (1-1)c | 3 (3-4)c | |
| A. flavus (8) | Nongerminated | 1 (0.5-1) | 0.12 (0.03-0.12) | 0.03 (0.03-0.06) |
| Germinated | 1 (1-1) | 0.5 (0.25-1) | 0.25 (0.12-0.25) | |
| Log2 of ratio | 0 (0-1) | 2 (2-3)c | 2.5 (2-3)c | |
a
For comparisons of the MECs between echinocandins, P was <0.01 for all comparisons, with the exception of the MEC values of micafungin versus those of anidulafungin for germinated conidia.
b
The ratio is expressed as the number of twofold drug dilutions (log2 of MEC for germinated conidia/MEC for nongerminated ratio).
c
For comparisons of the MECs between nongerminated and germinated conidia, P was <0.01 for the comparison of the corresponding MEC values.