TABLE 2.

EC₅ (or EC₅1) values generated with the E_max (or bell-shaped) model for the metabolic activities of germinated and nongerminated Aspergillus conidia in the presence of echinocandins

Species (no. of strains)	Conidial state	Median (range) EC5 (or EC51) (μg/ml)
		Caspofungina	Micafungina	Anidulafungina
A. fumigatus (11)	Nongerminated	0.67 (0.51-1.43)	0.04 (0.01-0.15)	0.03 (0.004-0.04)
	Germinated	1.2 (1.05-1.99)	0.05 (0.04-0.12)	0.11 (0.03-0.54)
Log2 of ratiob		0.96 (−0.05-1.96)c	0.67 (−1.49-1.93)	2.4 (0.7-4.2)c
A. terreus (8)	Nongerminated	0.65 (0.29-1.23)	0.07 (0.02-0.25)	0.01 (0.008-0.03)
	Germinated	1.06 (0.62-2.53)	0.14 (0.03-0.4)	0.10 (0.06-0.14)
Log2 of ratio		1.12 (−0.23-1.39)c	2.04 (1.6-2.26)c	2.97 (1-3.82)c
A. flavus (8)	Nongerminated	0.64 (0.42-0.96)	0.05 (0.02-0.11)	0.01 (0.007-0.03)
	Germinated	0.87 (0.62-1.11)	0.14 (0.06-0.61)	0.09 (0.06-0.38)
Log2 of ratio		0.43 (−0.18-0.87)	1.57 (0.64-2.44)c	2.96 (1.02-4.81)c

^aFor comparisons of the EC₅ values between the echinocandins, P was <0.01 for all comparisons, with the exception of the EC₅ values of micafungin versus anidulafungin for germinated conidia.

^bThe ratios are expressed as the numbers of twofold drug dilutions (log₂) for germinated conidia to those for nongerminated conidia.

^cFor comparisons of the EC₅ values between nongerminated and germinated conidia, P was <0.05 for comparisons of the corresponding EC₅ values.