TABLE 3.
Ymin values and percent difference in Ymin values generated by use of the Emax (or bell-shaped) model for the metabolic activity of germinated and nongerminated Aspergillus conidia in the presence of echinocandins
| Species (no. of strains) | Conidial state | Median (range) Ymin (%)
|
||
|---|---|---|---|---|
| Caspofungina | Micafungina | Anidulafunginb | ||
| A. fumigatus (11) | Nongerminated | 26 (21-50) | 25 (19-50) | 26 (21-51) |
| Germinated | 26 (13-49) | 29 (24-55) | 36 (21-65) | |
| Differencec | 3 (−9-11) | 3 (−14-19) | 6 (−17-18) | |
| A. terreus (8) | Nongerminated | 34 (14-62) | 29 (19-64) | 30 (17-62) |
| Germinated | 35 (15-66) | 37 (16-81) | 44 (24-76) | |
| Difference | 3 (−4-12) | 7 (−3-18) | 10 (0-21) | |
| A. flavus (8) | Nongerminated | 17 (14-23) | 17 (12-22) | 16 (13-22) |
| Germinated | 21 (16-28) | 20 (18-32) | 16 (14-22) | |
| Difference | 3 (−1-10) | 5 (−3-13) | 1 (−7-8) | |
a
P was <0.05 for nongerminated A. flavus conidia versus nongerminated A. fumigatus or A. terreus conidia and for germinated A. flavus conidia versus germinated A. terreus conidia.
b
P was <0.01 for nongerminated A. flavus conidia versus nongerminated A. fumigatus or A. terreus conidia and for germinated A. flavus conidia versus germinated A. fumigatus or A. terreus conidia.
c
The differences between germinated and nongerminated conidia are expressed here as the percent difference in metabolic activity.