TABLE 2.

Quinolone MICs for 28 strains with defined mutations in the QRDR

Strain no.	HMC strain no.	MIC (μg/ml)e						Mutation detected in QRDR off:
		DC-159a	CIPRO	LEVO	MOXI	GATI	GEMI	GyrA	ParC	ParE
1	1149a	0.25	16	4	0.25	1	0.25	S81F	S79Y
2	1151a	0.25	16	4	0.25	2	0.25		D83N, K137N	I460V
3	1058	0.5	16	8	0.5	2	0.125		S79F, K137N	I460V
4	1060	0.5	16	8	2	4	0.25	S81F	S79F, K137N	I460V
5	1066	0.5	16	8	2	4	0.25	S81F	S79F	I460V
6	1070	1	32	8	4	4	0.25	S81F	D83N	I460V
7	1073	1	8	8	2	4	0.125	S81F		I460V
8	1076	0.5	16	8	2	4	0.5	S81F	D83N	I460V
9	1146	1	>32	8	2	4	0.5	S81F		D435N
10	1147b	1	>32	8	4	8	1	S81F	S79F	I460V
11	1150	0.5	16	8	1	4	0.25	S81C	S79F	I460V
12	2538c	1	16	8	2	8	0.25	S81Y	S79F, K137N	I460V
13	5041	1	16	8	4	4	0.5	S81F	S79F
14	1055	1	32	16	4	8	0.5	S81F	S79F, K137N	I460V
15	1059	1	32	16	4	8	0.5	S81F	S79F, K137N	I460N
16	1071	1	32	16	4	8	0.5	S81F	S79F, K137N
17	1072	1	>32	16	4	8	0.5	S81F	S79Y	I460V
18	1074	0.5	16	16	2	4	0.5	S81F	S79F	I460V
19	1077	1	>32	16	4	8	0.25	S81Y	S79F
20	1078	1	>32	16	4	8	0.5	S81F	S79F	I460V
21	1139	1	32	16	4	8	0.25	S81F	S79F, K137N	I460V
22	1156	1	>32	16	4	8	0.1	S81F	S79F
23	1541	0.5	16	16	2	4	0.25	S81Y	S79F, K137N	I460V
24	2527	1	16	16	4	16	0.25	S81Y	S79F, K137N	I460V
25	2536	1	16	16	4	16	0.125	S81Y	S79F, K137N	I460V
26	4026	1	>32	16	4	16	0.5	S81Y	S79F, K137N	I460V
27	1062	1	>32	32	4	16	1	S81F	S79F	I460V
28	1068d	1	32	32	4	8	0.5	E85K	S79Y, K137N	I460V

^aHas efflux for ciprofloxacin and gemifloxacin.

^bHas efflux for gemifloxacin.

^cHas efflux for ciprofloxacin, levofloxacin, and gatifloxacin.

^dHas efflux for ciprofloxacin and levofloxacin.

^eCIPRO, ciprofloxacin; LEVO, levofloxacin; MOXI, moxifloxacin; GATI, gatifloxacin; GEMI, gemifloxacin.

^fNo mutation was detected in GyrB.