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Peptide binding to strain set
| Strain | Concn of drug bound (μg/ml [mean ± SD])a
|
|||
|---|---|---|---|---|
| RP-1 (40 μg) | Gramicidin D (32 μg) | hNP-1 (20 μg) | Daptomycin (6 μg) | |
| 616 (parental) | 12.4 ± 0.48 | 12.0 ± 3.0 | 13 ± 1.2 | 5.4 ± 0.83 |
| 629 (transitional) | 11.7 ± 0.10 | 10.0 ± 1.8 | 4.0 ± 0.5* | 1.61 ± 1.3* |
| 701 (daptomycin nonsusceptible) | 11.7 ± 0.15 | 11.0 ± 3.8 | 8.0 ± 1.1 | 2.32 ± 1.23* |
| 703 (daptomycin nonsusceptible) | 8.0 ± 0.34* | 9.0 ± 2.7* | 8.0 ± 1.6 | 2.24 ± 1.07* |
*, P < 0.05 versus the parental strain.
