TABLE 2.
MICs of graSR-derivative strains of N315 and Mu3a
| Strain | MIC (mg/liter) of indicated antimicrobial at indicated time
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Vancomycin
|
Teicoplanin
|
Oxacillin
|
Daptomycin
|
|||||
| 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | |
| N315 | 0.5 | 0.5 | 1 | 1 | 2 | 8 | 0.5 | 0.5 |
| N315(pYT3) | 0.5 | 0.5 | 0.5 | 0.5 | 4 | 4 | 0.5 | 0.5 |
| N315(pgraR*) | 1 | 1 | 0.5 | 0.5 | 0.25 | 0.25 | 1 | 1 |
| N315(pgraRn) | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 0.5 | 0.5 |
| N315ΔgraSR | 0.5 | 0.5 | 0.5 | 0.5 | 4 | 16 | 0.5 | 0.5 |
| N315ΔgraSR(pgraR*) | 1 | 1 | 0.5 | 0.5 | 2 | 4 | 1 | 1 |
| N315ΔgraSR(pgraSR*) | 1 | 1 | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 1 |
| Mu3 | 2 | 2 | 7 | 8 | 1,025 | >1,025 | 1 | 1 |
| Mu3(pYT3) | 1 | 2 | 6 | 6 | 1,025 | >1,025 | 1 | 2 |
| Mu3(pgraR*) | 4 | 4 | 6 | 7 | 1,025 | 1,025 | 3 | 3 |
| Mu3(pgraRn) | 2 | 2 | 5 | 6 | 1,025 | 1,025 | 3 | 3 |
| Mu3ΔgraSR | 1 | 1 | 3 | 4 | 1,025 | 1,025 | 0.5 | 0.5 |
| Mu3ΔgraSR(pgraR*) | 3 | 4 | 6 | 6 | 1,025 | 1,025 | 3 | 3 |
| Mu50 | 4 | 8 | 7 | 7 | 512 | 512 | 3 | 3 |
a
The drug concentrations for oxacillin were twofold dilutions from 0.25 mg/liter to 1,025 mg/liter. For the other three antibiotics, tested concentrations were 0.5 mg/liter, 1 through 10 mg/liter with a 1-mg/liter increment, and a twofold dilution from 16 to 1,024 mg/liter.