TABLE 1.
Noncompartmental pharmacokinetics of telavancin, following administration of a 60-minute intravenous infusion of 10 mg/kg once daily for 3 days, in 20 healthy adult subjectsa
| Parameter | Mean (SD) |
|---|---|
| Cmax (μg/ml) | 116 (30) |
| Tmax (h) | 1.00 (0) |
| AUC0-24 (μg·h/ml) | 785 (111) |
| t1/2 (h) | 7.41 (1.08) |
| CLss (ml/h/kg) | 13.0 (1.9) |
| MRT (h) | 9.42 (1.54) |
| Vdss (ml/kg) | 122 (22) |
| Cmin (μg/ml) | 8.11 (2.28) |
a
CLss, clearance at steady state; MRT, mean residence time; Tmax, time to Cmax; Vdss, volume of distribution at steady state.