TABLE 2.
Summary of cohort classification system and microbiological and clinical outcomes
| Cohort(s) | Pathogen criterion | MIC range | No. of patients (no. of pathogens) | No. (%) of microbiological curesc | No. (%) of clinical curesd |
|---|---|---|---|---|---|
| 1 | E. coli only | 0.12-1 | 34 (35) | 35 (100) | 32 (94) |
| 2 | ≥1 GNa | 0.12-1 | 16 (24) | 22 (92) | 14 (88) |
| 3 | ≥1 GNa + ≥1 anaerobe | 0.06-4 | 21 (47) | 39 (83) | 16 (76) |
| 4 | ≥1 GNa + ≥1 GPb | 0.06-1 | 21 (50) | 44 (88) | 18 (86) |
| 5 | Other | 0.004-4 | 31 (60) | 54 (90) | 27 (87) |
| 1+2+3 | ≥1 GNa ± ≥1 anaerobe | 0.06-4 | 71 (106) | 96 (91) | 62 (87) |
a
Gram-negative Enterobacteriaceae organism.
b
Gram-positive organism.
c
Pathogen-level microbiological response.
d
Patient-level clinical response.