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Schematic diagram of C. elegans lamin. The numbers represent the number of amino acids in each subdomain, including the amino (head) and carboxyl (tail) domains and the different coils (1A, 1B, 2A, and 2B) and linker regions (L1, L12, and L2) in the rod domain. Also marked are the positions of the stutter in coil 2B, the NLS, and the Ig fold. Arrows indicate the location of mutated amino acid residues. E, EDMD; P, HGPS; D, DCM; F, FPLD.
