Fig. 5.
hip is a dominant suppressor of PEV. (A) Variegating eye pigmentation in In(1)wm4 flies heterozygous for the hip41 allele (haplo condition) and the P insertion P[hip] (triplo condition). Both decreasing and increasing the dose of hip causes an increase in pigmentation when compared with control eyes. Eye pigmentation was quantified to determine wm4 expression. Representative eye phenotypes of hemizygous wm4 males are shown. (B) In a different system, a translocation of the P(GawB) transposon juxtaposed to the chromocentric heterochromatin results in mottled eye pigmentation. As in A, hyperexpression as well as reduction of hip suppresses heterochromatin-mediated inactivation of miniwhite expression. +, wild-type hip allele.