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. 2007 Dec 27;105(1):252–257. doi: 10.1073/pnas.0710735105

Fig. 3.

Fig. 3.

Promoter hypermethylation and intragenic SINE hypomethylation in the UNC5D gene. (A) This gene on chromosome 8 shows hypermethylation of the promoter-associated CpG island (blue circles) and hypomethylation of multiple intragenic SINE elements (red circles). (B) Bisulfite sequencing confirms the methylation status of the promoter and its proximal SINE element. The purple bars indicate the regions analyzed by bisulfite sequencing. Black boxes indicate exons, and the arrow shows the transcription start site.