Table 1.
Metabolic characteristics of 4-month-old Ankrd26 mutant mice
| Characteristic | WT male | Mutant male | WT female | Mutant female |
|---|---|---|---|---|
| Body weight, g | 28.4 ± 1.3 | 40.1 ± 1.2* | 23.2 ± 1.6 | 40.5 ± 3.1* |
| Fat mass, g | 3.6 ± 0.9 | 9.5 ± 1.5* | 3.5 ± 1.2 | 16.2 ± 2.4* |
| Fat mass, % body weight | 12.2 ± 2.8 | 23.2 ± 3.3* | 14.1 ± 3.8 | 39.3 ± 2.9* |
| Lean mass, g | 23.7 ± 0.8 | 29.1 ± 0.7* | 18.3 ± 0.5 | 22.8 ± 1.1* |
| Lean mass, % body weight | 83.5 ± 2.4 | 72.9 ± 3.2* | 79.8 ± 3.5 | 57.2 ± 2.7* |
| Length, mm | 83 ± 1.2 | 91 ± 2 | 80 ± 1 | 89 ± 2* |
| Inguinal fat, g | 0.4 ± 0.06 | 1.0 ± 0.23 | 0.4 ± 0.2 | 1.4 ± 0.22* |
| Gonadal fat, g | 0.4 ± 0.08 | 1.1 ± 0.29 | 0.6 ± 0.3 | 2.3 ± 0.35* |
| Brown fat, g | 0.1 ± 0.01 | 0.2 ± 0.04 | 0.08 ± 0.02 | 0.3 ± 0.11 |
| Liver, g | 1.5 ± 0.1 | 2.0 ± 0.20 | 1.1 ± 0.1 | 1.6 ± 0.22 |
| Kidney, g | 0.4 ± 0.01 | 0.45 ± 0.20 | 0.3 ± 0.01 | 0.33 ± 0.01* |
| Heart, g | 0.15 ± 0.01 | 0.2 ± 0.02* | 0.11 ± 0.01 | 0.15 ± 0.01* |
| Serum glucose, mg/dl | 243 ± 9 | 248 ± 29 | 215 ± 17 | 281 ± 35 |
| Insulin, ng/ml | 0.44 ± 0.05 | 1.4 ± 0.82 | 0.34 ± 0.07 | 0.70 ± 0.11 |
| Triglyceride, mg/dl | 79 ± 14 | 76 ± 20 | 59 ± 21 | 75 ± 21 |
| Free fatty acids, mM | 0.2 ± 0.04 | 0.23 ± 0.02 | 0.35 ± 0.06 | 0.24 ± 0.03 |
| Leptin, ng/ml | 8.8 ± 3.8 | 25.3 ± 9.8 | 8.3 ± 4.0 | 49 ± 16* |
| Adiponectin, μg/ml | 8.9 ± 0.4 | 9.7 ± 1.1 | 17.6 ± 1.8 | 29.7 ± 5.0 |
n = 4–5 mice per group.
*, P < 0.05 versus WT mice of the same sex.