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Modulation of facilitation of CaV2.1 channels by binding of CaMKII. CaV2.1 channels with β2a subunits were expressed in tsA-201 cells. (A) Normalized CaV2.1 currents under the indicated conditions during 1-s depolarizations from −80 to +20 mV (or 0 mV for Ba2+) (n = 6–10). (B) Facilitation of ICa during a train of 5-ms pulses at 100 Hz from −80 to +20 mV (or 0 mV for Ba2+) (n = 7–11). Current amplitudes are normalized to the initial current amplitude in each train.
